박준우June-Woo Park
출신대학, 전공 |
미시간주립대학교, 환경독성학 |
학위 |
이학박사, 미시간주립대학교 |
소속 |
안전성평가연구소 환경위해성연구부 환경생물연구그룹 과학기술연합대학원대학교 |
직위 |
환경위해성연구부장, 책임연구원, 전공책임교수 |
이메일 |
jwpark@kitox.re.kr |
홈페이지 |
|
연구분야
A. 환경 중 잠재적 유해물질의 유해성 평가
1. 환경 중 내분비계 교란 물질의 유해성 평가
2. 환경 중 입자성 물질에 대한 유해성 평가: (초)미세플라스틱, 나노물질
3. 생활환경화학물질의 복합노출에 대한 독성 평가
4. 분자적 수준에서의 독성 기전 규명
B. 신규 화학물질 (의약품 및 화장품)의 유효성 평가
C. 표준시험법 개발
1. ISO 시험법 개발: 제거된 제브라피쉬를 이용한 나노물질의 독성 평가
2. OECD 시험법의 개선 및 개발: 나노물질에 대한 기존 OECD 시험법의 적용성 검토 및 개선
3. 국립환경과학원 고시화 제안: OECD 시험법 (TG NO. 236)의 국내 시험법으로 제안
D. 예측모델 개발
1. 환경 또는 인체 유해성의 조기 검출을 위한 분자적 수준의 마커 개발
연구논문
A. 2020 년
1. Kim YS, Kim JK, Hanh BTB, Kim SY, Kim HJ, Kim YJ, Jeon SM, Park CR, Oh GT, Park JW, Kim JM, Jang J, Jo EK. The Peroxisome Proliferator-Activated Receptor α- Agonist Gemfibrozil Promotes Defense Against Mycobacterium abscessus Infections. Cells. 2020 Mar 6;9(3):648. doi: 10.3390/cells9030648. PMID: 32155958
2. Hanh BTB, Park JW, Kim TH, Kim JS, Yang CS, Jang K, Cui J, Oh DC, Jang J. Rifamycin O, An Alternative Anti-Mycobacterium abscessus Agent. Molecules. 2020 Mar 31;25(7):1597. doi: 10.3390/molecules25071597. PMID: 32244387.
3. Kim YS, Kim JK, Hanh BTB, Kim SY, Kim HJ, Kim YJ, Jeon SM, Park CR, Oh GT, Park JW, Kim JM, Jang J, Jo EK. The Peroxisome Proliferator-Activated Receptor α- Agonist Gemfibrozil Promotes Defense Against Mycobacterium abscessus Infections. Cells. 2020 Mar 6;9(3):648. doi: 10.3390/cells9030648. PMID: 32155958.
4. Hanh BTB, Kim TH, Park JW, Lee DG, Kim JS, Du YE, Yang CS, Oh DC, Jang J. Etamycin as a Novel Mycobacterium abscessus Inhibitor. Int J Mol Sci. 2020 Sep 21;21(18):E6908. doi: 10.3390/ijms21186908. PMID: 32967077.
5. Kwon YS, Jung JW, Kim YJ, Park CB, Shon JC, Kim JH, Park JW, Kim SG, Seo JS. Proteomic analysis of whole-body responses in medaka (Oryzias latipes) exposed to benzalkonium chloride. J Environ Sci Health A Tox Hazard Subst Environ Eng. 2020 Jul 21:1-11. doi: 10.1080/10934529.2020.1796117. Online ahead of print. PMID: 32693679.
6. Kim YJ, Lee SH, Jeon SM, Silwal P, Seo JY, Hanh BTB, Park JW, Whang J, Lee MJ, Heo JY, Kim SH, Kim JM, Song GY, Jang J, Jo EK. Sirtuin 3 is essential for host defense against Mycobacterium abscessus infection through regulation of mitochondrial homeostasis. Virulence. 2020 Dec;11(1):1225-1239. doi: 10.1080/21505594.2020.1809961.PMID: 32835604.
7. Jung JW, Kang JS, Choi J, Park JW. Chronic toxicity of endocrine disrupting chemicals used in plastic products in Korean resident species: Implications for aquatic ecological risk assessment. Ecotoxicol Environ Saf. 2020 Apr 1;192:110309. doi: 10.1016/j.ecoenv.2020.110309. Epub 2020 Feb 12. PMID: 32061985.
B. 2019년
1. Kim TH, Hanh BTB, Kim G, Lee DG, Park JW, Lee SE, Kim JS, Kim BS, Ryoo S, Jo EK, Jang J. Thiostrepton: A Novel Therapeutic Drug Candidate for Mycobacterium abscessus Infection. Molecules. 2019 Dec 10;24(24):4511. doi: 10.3390/molecules24244511. PMID: 31835481.
2. Johari SA, Rasmussen K, Gulumian M, Ghazi-Khansari M, Tetarazako N, Kashiwada S, Asghari S, Park JW, Yu IJ. Introducing a new standardized nanomaterial environmental toxicity screening testing procedure, ISO/TS 20787: aquatic toxicity assessment of manufactured nanomaterials in saltwater Lakes using Artemia sp. nauplii. Toxicol Mech Methods. 2019 Feb;29(2):95-109. doi: 10.1080/15376516.2018.1512695. Epub 2018 Sep 27. PMID: 30113242.
3. Choi JS, Hong SH, Park JW. Evaluation of microplastic toxicity in accordance with different sizes and exposure times in the marine copepod Tigriopus japonicus. Mar Environ Res. 2019 Nov 9:104838. doi: 10.1016/j.marenvres.2019.104838. Online ahead of print. PMID: 31733910.
4. Kang JS, Ahn TG, Park JW. Perfluorooctanoic acid (PFOA) and perfluooctane sulfonate (PFOS) induce different modes of action in reproduction to Japanese medaka (Oryzias latipes). J Hazard Mater. 2019 Apr 15;368:97-103. doi: 10.1016/j.jhazmat.2019.01.034. Epub 2019 Jan 14. PMID: 30665113.
C. 2018년
1. Choi JS, Jung YJ, Hong NH, Hong SH, Park JW. Toxicological effects of irregularly shaped and spherical microplastics in a marine teleost, the sheepshead minnow (Cyprinodon variegatus). Mar Pollut Bull. 2018 Apr;129(1):231-240. doi: 10.1016/j.marpolbul.2018.02.039. Epub 2018 Feb 27. PMID: 29680542.
2. Kang JS, Park JW. Insight on cytotoxic effects of silver nanoparticles: Alternative androgenic transactivation by adsorption with DHT. Sci Total Environ. 2018 Mar 15;618:712-717. doi: 10.1016/j.scitotenv.2017.08.059. Epub 2017 Nov 10. PMID: 29129328
D. 2017년
1. Kwak JI, Park JW, An YJ. Effects of silver nanowire length and exposure route on cytotoxicity to earthworms. Environ Sci Pollut Res Int. 2017 Jun;24(16):14516-14524. doi: 10.1007/s11356-017-9054-x. Epub 2017 Apr 27. PMID: 28452028.
E. 2016년
1. Kang JS, Choi JS, Park JW. Transcriptional changes in steroidogenesis by perfluoroalkyl acids (PFOA and PFOS) regulate the synthesis of sex hormones in H295R cells. Chemosphere. 2016 Jul;155:436-443. doi: 10.1016/j.chemosphere.2016.04.070. Epub 2016 Apr 30. PMID: 27139122.
2. Kang JS, Bong J, Choi JS, Henry TB, Park JW. Differentially transcriptional regulation on cell cycle pathway by silver nanoparticles from ionic silver in larval zebrafish (Danio rerio). Biochem Biophys Res Commun. 2016 Oct 28;479(4):753-758. doi: 10.1016/j.bbrc.2016.09.139. Epub 2016 Sep 28. PMID: 27693782.
F. 2015년
1. Choi S, Kim S, Bae YJ, Park JW, Jung J. Size-dependent toxicity of silver nanoparticles to Glyptotendipes tokunagai. Environ Health Toxicol. 2015 May 14;30:e2015003. doi: 10.5620/eht.e2015003. eCollection 2015. PMID: 26184045.
G. 2014년
1. Kim WK, Lee SK, Park JW, Choi K, Cargo J, Schlenk D, Jung J. Integration of multi-level biomarker responses to cadmium and benzo[k]fluoranthene in the pale chub (Zacco platypus). Ecotoxicol Environ Saf. 2014 Dec;110:121-8. doi: 10.1016/j.ecoenv.2014.08.025. Epub 2014 Sep 16. PMID: 25217733.
2. Park J, Kim S, Yoo J, Lee JS, Park JW, Jung J. Effect of salinity on acute copper and zinc toxicity to Tigriopus japonicus: the difference between metal ions and nanoparticles. Mar Pollut Bull. 2014 Aug 30;85(2):526-31. doi: 10.1016/j.marpolbul.2014.04.038. Epub 2014 May 16. PMID: 24837323.
3. Kang JS, Choi JS, Kim WK, Lee YJ, Park JW. Estrogenic potency of bisphenol S, polyethersulfone and their metabolites generated by the rat liver S9 fractions on a MVLN cell using a luciferase reporter gene assay. Reprod Biol Endocrinol. 2014 Nov 4;12:102. doi: 10.1186/1477-7827-12-102. PMID: 25371027.
4. Jang MH, Kim WK, Lee SK, Henry TB, Park JW. Uptake, tissue distribution, and depuration of total silver in common carp (Cyprinus carpio) after aqueous exposure to silver nanoparticles. Environ Sci Technol. 2014 Oct 7;48(19):11568-74. doi: 10.1021/es5022813. Epub 2014 Sep 15. PMID: 25171685.
5. Kim WK, Park JW, Lim ES, Lee SK, Kim J, Kim S, Lee SW, Choi K, Jung J. Tissue-specific antioxidant responses in pale chub (Zacco platypus) exposed to copper and benzo[a]pyrene. Bull Environ Contam Toxicol. 2014 May;92(5):540-5. doi: 10.1007/s00128-014-1213-x. Epub 2014 Jan 30.PMID: 24477393.
6. Park JW, Oh JH, Kim WK, Lee SK. Toxicity of citrate-coated silver nanoparticles differs according to method of suspension preparation. Bull Environ Contam Toxicol. 2014 Jul;93(1):53-9. doi: 10.1007/s00128-014-1296-4. Epub 2014 May 20. PMID: 24841540.
7. Seo J, Kim S, Choi S, Kwon D, Yoon TH, Kim WK, Park JW, Jung J. Effects of physiochemical properties of test media on nanoparticle toxicity to Daphnia magna Straus. Bull Environ Contam Toxicol. 2014 Sep;93(3):257-62. doi: 10.1007/s00128-014-1337-z. Epub 2014 Jul 26. PMID: 25063370.
H. 2013년
I. 2012년
1. Park JW, Heah TP, Gouffon JS, Henry TB, Sayler GS. Global gene expression in larval zebrafish (Danio rerio) exposed to selective serotonin reuptake inhibitors (fluoxetine and sertraline) reveals unique expression profiles and potential biomarkers of exposure. Environ Pollut. 2012 Aug;167:163-70. doi: 10.1016/j.envpol.2012.03.039. Epub 2012 May 9. PMID: 22575097.
J. 2011년
1. Park JW, Henry TB, Ard S, Menn FM, Compton RN, Sayler GS. The association between nC60 and 17α-ethinylestradiol (EE2) decreases EE2 bioavailability in zebrafish and alters nanoaggregate characteristics. Nanotoxicology. 2011 Sep;5(3):406-16. doi: 10.3109/17435390.2010.525329. Epub 2010 Oct 25. PMID: 20969539.
K. 2010년
1. Park JW, Henry TB, Menn FM, Compton RN, Sayler G. No bioavailability of 17α-ethinylestradiol when associated with nC60 aggregates during dietary exposure in adult male zebrafish (Danio rerio). Chemosphere. 2010 Nov;81(10):1227-32. doi: 10.1016/j.chemosphere.2010.09.036. PMID: 20937515.
L. 2009년
1. Park JW, Tompsett AR, Zhang X, Newsted JL, Jones PD, Au DW, Kong R, Wu RS, Giesy JP, Hecker M. Advanced fluorescence in situ hybridization to localize and quantify gene expression in Japanese medaka (Oryzias latipes) exposed to endocrine-disrupting compounds. Environ Toxicol Chem. 2009 Sep;28(9):1951-62. doi: 10.1897/08-574.1. PMID: 19469586.
M. 2008년
1. Park JW, Tompsett A, Zhang X, Newsted JL, Jones PD, Au D, Kong R, Wu RS, Giesy JP, Hecker M. Fluorescence in situ hybridization techniques (FISH) to detect changes in CYP19a gene expression of Japanese medaka (Oryzias latipes). Toxicol Appl Pharmacol. 2008 Oct 15;232(2):226-35. doi: 10.1016/j.taap.2008.06.012. Epub 2008 Jul 2. PMID: 18644401.
2. Zhang X, Hecker M, Park JW, Tompsett AR, Newsted J, Nakayama K, Jones PD, Au D, Kong R, Wu RS, Giesy JP. Real-time PCR array to study effects of chemicals on the Hypothalamic-Pituitary-Gonadal axis of the Japanese medaka. Aquat Toxicol. 2008 Jul 7;88(3):173-82. doi: 10.1016/j.aquatox.2008.04.009. Epub 2008 Apr 24. PMID: 18534694.
3. Zhang X, Hecker M, Park JW, Tompsett AR, Jones PD, Newsted J, Au DW, Kong R, Wu RS, Giesy JP. Time-dependent transcriptional profiles of genes of the hypothalamic-pituitary-gonadal axis in medaka (Oryzias latipes) exposed to fadrozole and 17beta-trenbolone. Environ Toxicol Chem. 2008 Dec;27(12):2504-11. doi: 10.1897/08-082.1. PMID: 18693774.
4. Zhang X, Hecker M, Tompsett AR, Park JW, Jones PD, Newsted J, Au D, Kong R, Wu RS, Giesy JP. Responses of the medaka HPG axis PCR array and reproduction to prochloraz and ketoconazole. Environ Sci Technol. 2008 Sep 1;42(17):6762-9. doi: 10.1021/es800591t. PMID: 1880056.
N. 2007년
1. Park JW, Bradford CM, Rinchard J, Liu F, Wages M, Waters A, Kendall RJ, Anderson TA, Theodorakis CW. Uptake, elimination, and relative distribution of perchlorate in various tissues of channel catfish. Environ Sci Technol. 2007 Nov 1;41(21):7581-6. doi: 10.1021/es071365n. PMID: 18044545.
O. 2006년
1. Bradford CM, Park JW, Rinchard J, Anderson TA, Liu F, Theodorakis CW. Uptake and elimination of perchlorate in eastern mosquitofish. Chemosphere. 2006 Jun;63(9):1591-7. doi: 10.1016/j.chemosphere.2005.08.073. Epub 2005 Nov 21. PMID: 16303168.
2. Park JW, Rinchard J, Liu F, Anderson TA, Kendall RJ, Theodorakis CW. The thyroid endocrine disruptor perchlorate affects reproduction, growth, and survival of mosquitofish. Ecotoxicol Environ Saf. 2006 Mar;63(3):343-52. doi: 10.1016/j.ecoenv.2005.04.002. PMID: 16507371.
3. Theodorakis C, Rinchard J, Anderson T, Liu F, Park JW, Costa F, McDaniel L, Kendall R, Waters A. Perchlorate in fish from a contaminated site in east-central Texas. Environ Pollut. 2006 Jan;139(1):59-69. doi: 10.1016/j.envpol.2005.04.030. Epub 2005 Jul 1. PMID: 15993996.
4. Theodorakis CW, Rinchard J, Carr JA, Park JW, McDaniel L, Liu F, Wages M. Thyroid endocrine disruption in stonerollers and cricket frogs from perchlorate-contaminated streams in east-central Texas. Ecotoxicology. 2006 Feb;15(1):31-50. doi: 10.1007/s10646-005-0040-6. Epub 2005 Dec 9. PMID: 16341611.
5. Park JW, Hecker M, Murphy MB, Jones PD, Solomon KR, Van Der Kraak G, Carr JA, Smith EE, du Preez L, Kendall RJ, Giesy JP. Development and optimization of a Q-RT PCR method to quantify CYP19 mRNA expression in testis of male adult Xenopus laevis: comparisons with aromatase enzyme activity. Comp Biochem Physiol B Biochem Mol Biol. 2006 May;144(1):18-28. doi: 10.1016/j.cbpb.2006.01.003. Epub 2006 Feb 21. PMID: 16492402.
P. 2005년
1. Hecker M, Kim WJ, Park JW, Murphy MB, Villeneuve D, Coady KK, Jones PD, Solomon KR, Van Der Kraak G, Carr JA, Smith EE, du Preez L, Kendall RJ, Giesy JP; Syngenta Crop Protection Inc. Plasma concentrations of estradiol and testosterone, gonadal aromatase activity and ultrastructure of the testis in Xenopus laevis exposed to estradiol or atrazine. Aquat Toxicol. 2005 May 15;72(4):383-96. doi: 10.1016/j.aquatox.2005.01.008. PMID: 15848257.
2. Hecker M, Park JW, Murphy MB, Jones PD, Solomon KR, Van Der Kraak G, Carr JA, Smith EE, du Preez L, Kendall RJ, Giesy JP. Effects of atrazine on CYP19 gene expression and aromatase activity in testes and on plasma sex steroid concentrations of male African clawed frogs (Xenopus laevis). Toxicol Sci. 2005 Aug;86(2):273-80. doi: 10.1093/toxsci/kfi203. Epub 2005 May 18. PMID: 15901915.